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We present a novel series of HIV integrase inhibitors, showing IC 50 s ranging from 0.01 to over 370μM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure–activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for...
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