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The serine/threonine kinase Pim‐1 is emerging as a promising target for cancer therapeutics. Much attention has recently been focused on identifying potential Pim‐1 inhibitor candidates for the treatment of haematopoietic malignancies. The outcome of a rational drug‐design project has recently been reported [Nakano et al. (2012), J. Med. Chem.55, 5151–5156]. The report described the process of optimization...
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