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Here, we provide an alternative synthesis of the natural bromophenol 3,4‐dibromo‐5‐(2,3‐dibromo‐4,5‐dihydroxybenzyl)‐6‐(ethoxymethyl)benzene‐1,2‐diol (3) and the first synthesis of (4,5‐dihydroxy‐2‐methylphenyl)(3,4‐dihydroxyphenyl)methanone (18) and its brominated derivatives 19–21. The compounds were characterized and tested against the two most studied members of the pH regulatory enzyme family,...
A series of 1‐aryl‐3‐isopropylamino‐1‐propanone hydrochlorides 1 and a related heterocyclic analog 2 as candidate antineoplastic agents were prepared and the rationale for designing these compounds is presented. A specific objective in this study is the discovery of novel compounds possessing growth‐inhibiting properties of hepatoma cells. The compounds in series 1 and 2 were prepared and their structures...
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