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15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is an enzyme that catalyzes the conversion of prostaglandin E2 (PGE2)to a biologically inactive 15-keto-PGE2. 15-PGDH has been considered to be a tumor suppressor as its expression is frequently repressed in human malignancies. In our study, we observed that H2O2 suppresses the expression of 15-PGDH in both concentration and time dependent manners. H2O2...
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