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Background
The aim of the present study was to compare insulin resistance and metabolic changes using a global lipidomic approach.
Methods
Rats were fed a high‐fat diet (HFD) or a high‐fructose diet (HFrD) for 12 weeks to induce insulin resistance (IR) syndrome. After 12 weeks feeding, physiological and biochemical parameters were examined. Insulin sensitivity and plasma metabolites were evaluated...
The heart is a highly adaptive organ that demonstrates remarkable structural, functional, and metabolic remodeling in response to physiological and pathological stimuli. We hypothesize that the heart undergoes differential adaptations in high-fat and high-fructose diet, resulting in a distinct phenotype.High-fat and high-fructose diet-induced obese and non-obese insulin resistance (IR) rat models...
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