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1. GABA-mediated inhibitory responses were induced in spontaneously active Purkinje cells by parallel fibre stimulation in cerebellar slices or in urethane-anaesthetised rats. Effects of agonist and inverse agonist benzodiazepine (BDZ) receptor ligands were compared in the preparations.2. Purkinje cells fired simple spikes at higher rates in slice preparations while complex spikes were seldom (in...
Recently, a role of IL-1 in the central nervous system has been described, principally a fever-inducing effect in the hypothalamus through a prostaglandin second messenger system. IL-1 has also been shown to potentiate gamma-aminobutyric acid (GABA A ) responses in embryonic chick neurones. This study describes the investigation of the effect of IL-1 on GABA A responses within the...
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