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Cytidine‐5′‐diphosphocholine (CDP‐choline) is a widely used neuroprotective drug for multiple indications. In industry, CDP‐choline is synthesized by a two‐step cell culture/permeabilized cell biotransformation method because substrates often do not enter cells in an efficient manner. This study develops a novel one‐step living cell fermentation method for CDP‐choline production. For this purpose,...
Pichia pastoris expression system has been widely used in recombinant protein production. So far the majority of heterologous proteins are expressed by methanol inducible promoter PAOX1 and constitutive promoter PGAP. The use of other promoters is rather limited. Here we selected 16 potentially efficient and regulatory promoter candidates based on the RNA‐seq and RNA folding free energy ΔG data. GFP...
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