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The mechanisms of planar cell polarity are being revealed by genetic analysis. Recent studies have provided new insights into interactions between three proteins involved in planar cell polarity: Flamingo, Frizzled and Van Gogh.
Background: Planar polarity refers to the asymmetry of a cell within the plane of the epithelium; for example, cells may form hairs that point in a posterior direction, or cilia may beat in one way. This property implies that cells have information about their orientation; we wish to understand the nature of this information. Relevant also is the body plan of insects, which, in the ectoderm and somatic...
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