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Focused ultrasound combined with microbubbles has shown to be a promising technique to induce noninvasively the localized BBB opening. The purpose of the present study is to explore the potential application of curcumin-loaded polysorbate 80-coated cerasomes (CPC) for treatment of Parkinson's disease using focused ultrasound. The CPC nanoparticles were fabricated and characterized and the optimal...
The aim of our study was to investigate the use of targeted ultrasound microbubbles (MBs) for molecular imaging of murine endothelial CD81 expression. In the study, the anti-CD81-coated MBs was successfully prepared and characterizated. Murine bEnd.3 cells were stimulated with phenazine methosulfate (PMS) to induce the up-regulation of CD81 expression. Changes in CD81 expression after stimulation...
Previous studies showed that the concentration of ultrasound contrast agents (UCAs) during imaging would impact greatly on the accuracy of flow velocity measurements using ultrasonic particle image velocimetry (Echo PIV) technique. This paper presents a texture-based method to identify the optimum concentration of UCAs for Echo PIV. The first-order and seconded-order texture features, standard deviation,...
This paper presents a high-resolution microscale ultrasonic particle image velocimetry technique (termed as Micro-EPIV) for measuring multi-component velocity vectors in microscale opaque flows such as blood and biofluid flow in microvessel. The method was tested by in vitro flow imaging and in vivo small animal blood flow imaging studies. The bioflow and blood flow were seeded with ultrasound contrast...
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