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Allocolchicinoids with B- and C-ring variations were synthesized using sequential enyne-metathesis/ Diels–Alder reactions (A→AB→ABC approach) and evaluated for their inhibitory effect on tubulin assembly in vitro. (−)-Allocolchicine 11 with methyl ester at C10 and (±)-cyclopropyl allocolchicinoid 32 exhibit similar activity than (−)-colchicine (1), probably derived from a similar flexibility in the...
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