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The formulas for heart rate (HR) correction of QT interval have been shown to overcorrect or undercorrect this interval with changes in HR. A Holter-monitoring method avoiding the need for any correction formulas is proposed as a means to assess drug-induced QT interval changes. A thorough QT study included 2 single doses of the α 1 -adrenergic receptor blocker alfuzosin, placebo, and a...
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