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Small molecule sodium ion channel blockers with a pharmacophore of α-aminoamide have exhibited anti-allodynia effects on neuropathic pain. A library of new α-aminoamide derivatives containing a scaffold of substituted benzene were designed and synthesized. These compounds were evaluated in mice formalin model and they exhibited significant analgesic activities. However, the anti-allodynia mechanism...
A new triterpene and a saponin, named 2α,3β,23-trihydroxyurs-20-en-28-oic acid (1) and 2α,3β,23-trihydroxyurs-20-en-28-oic acid O-α-l-rhamnopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→6)-O-β-d-glucopyranosyl ester (2), have been isolated from the aerial part of Centella asiatica. Their structures were elucidated by spectral methods, including 2D-NMR spectra.
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