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Huangqi Guizhi Wuwu decoction (HGWD) is an effective traditional Chinese medicine prescription, which is used for treating blood arthralgia in the clinic. However, its material basis has not been studied yet. Herein, a new and highly sensitive ultra‐high‐performance liquid chromatography–quadrupole‐time of flight–MS (UHPLC–Q‐TOF–MS) technique is proposed and used for the high‐resolution and accurate...
Poloxamer (PL)188 is a commonly used pharmaceutical excipient with unique physicochemical properties. In this study, an MSALL quantitative method for the determination of PL188 in rat plasma by UHPLC–Q‐TOF/MS was developed and validated. PL188 was analyzed on PLRP‐S reversed‐phase column (50 × 4.6 mm, 8 μm, 1,000 Å) with mobile phase 0.1% formic acid–water and 0.1% formic acid in acetonitrile–isopropanol...
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