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Alkaline phosphatases are found in different living species and play crucial roles in various significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing physiological compounds, contributing to DNA synthesis, bone calcification, and attenuation of inflammation. They are homodimeric enzymes; each subunit contains one magnesium ion and two zinc ions crucial for the catalytic...
A series of new coumarin–triazolothiadiazine hybrid compounds (5a–j) was designed and synthesized by using the molecular hybridization concept. The cyclocondensation reaction involves the coumarinyl 4‐amino‐1,2,4‐triazole and a range of bromo‐acetophenones, delivering the desired products in good yields. The structures of the synthesized compounds were established on the basis of spectro‐analytical...
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