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We hypothesized that moderate cardiac‐selective overexpression of the angiotensin II type 2 receptor (AT2R) would protect the myocardium from ischaemic injury after a myocardial infarction (MI) induced by coronary artery ligation. For in vitro studies, adenoviral vector expressing genomic DNA of AT2R and enhanced green fluorescence protein (EGFP) was used to overexpress AT2R in rat neonatal cardiac...
Myocardial infarction (MI) results in cell death, development of interstitial fibrosis, ventricular wall thinning and ultimately, heart failure. Angiotensin‐(1–7) [Ang‐(1–7)] has been shown to provide cardioprotective effects. We hypothesize that lentivirus‐mediated overexpression of Ang‐(1–7) would protect the myocardium from ischaemic injury. A single bolus of 3.5 × 108 transducing units of lenti‐Ang‐(1–7)...
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