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The hypothalamic neuropeptide orexin (hypocretin) influences a range of behaviors ranging from feeding to sleep and arousal. While genetic studies in rodents first demonstrated a role of orexin in narcolepsy with cataplexy, more recent work has brought attention to the role of orexin in drug addiction. Orexin influences many aspects of drug addiction, including drug dependence, reward, and reinstatement...
Orexin (or hypocretin) has been implicated in mediating drug addiction and reward. Here, we investigated orexin's contribution to morphine-induced behavioral sensitization and place preference. Orexin−/− (OKO) mice and littermate wild-type (WT) controls (n=56) and C57BL/6J mice (n=67) were tested for chronic morphine-induced locomotor sensitization or for conditioned place preference (CPP) for a morphine-...
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