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Abstract.Rationale: Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. Objectives: Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low performance PPI. Methods: Three strains of mice C57Bl/6J, 129S6/SvEvTac and...
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