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AbstractThe pleiotropic transcription factor NF-B is localized in the cytoplasm bound to its inhibitory subunit IB. The predominant form of NF-B is a p50/p65 heterodimer which can be released from IB- and migrate to the nucleus. Previous studies have shown that IB-/ mice die 8 to 10 days postnatally, showing runting and a severe dermatitis. However, the organ distribution of mouse IB-, the exon-intron...
AbstractNFKB2 is a member of the NFKB/Rel gene family, which is known to be a pivotal regulator of the acute phase and immune responses. NF-B2 is initially synthesized as a 100000 Mr protein which needs to be processed in order to bind DNA, either as homodimer or as heterodimer with other members of the NF-B/Rel family. The unprocessed form of NF-B2 acts as an IB-like protein. Therefore, NF-B2 has...
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