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Experimental and occupational inhalational exposure to oxygenate fuel additives in reformulated gasoline has been reported to induce neurological symptoms (e.g., headache, nausea, dizziness). We reported previously that the ether additives (methyl-t-butyl ether (MTBE), t-amyl-methyl ether (TAME) and ethyl-t-butyl ether (ETBE)) and their metabolites (t-amyl alcohol (TAA), t-butyl alcohol (TBA) and...
As a foundation for evaluating potential mechanisms of the neurological effects (e.g. headache, nausea, dizziness) of some octane boosters, we studied the γ-aminobutyric acid A (GABA A ) receptor in a series of binding assays in membranes from rat brain. The GABA A receptor was probed using the radioligand [ 3 H]t-butylbicycloorthobenzoate ([ 3 H]TBOB) which...
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