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Hyperosmotic (405 mosmol/l) exposure of RAW 264.7 mouse macrophages led to a stimulation of betaine uptake and an increase in betaine transporter (BGT-1) mRNA levels. Conversely, hypoosmotic (205 mosmol/l) exposure decreased betaine uptake and diminished BGT-1 mRNA levels. Betaine uptake was Na + -dependent and was inhibited by about 90% by GABA, whereas inhibition by methylaminoisobutyrate...
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