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In this study, a new compound PPD‐Arg (Tos) (PAT), an arginine derivative of 20(s)‐PPD, was synthesized via Fmoc‐Arg (Tos)‐OH and 20(s)‐PPD. The pharmacokinetic properties in rats, in vitro cytotoxicity, and cell apoptosis rates of protopanaxadiol (PPD) and PAT were determined. A sensitive bioanalytical method for pharmacokinetics using ultra‐performance liquid chromatography coupled with time‐of‐flight...
Although the chemical components of Panax notoginseng (PN) and Panax ginseng (PG) are similar, their bioactivities are different. In this study, the differential bioactivities of PN and PG were used as the research object. First, the different metabolites in the plasma after oral administration of PN and PG were analyzed using a UPLC‐Q/TOF‐MS‐based metabolomics approach. Afterward, the metabolite‐target‐...
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