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Cytokine‐expression profiles revealed IL‐1ß highly upregulated in rejecting skin of limb allografts. We investigate the effect of intragraft treatment with a neutralizing IL‐1β antibody in limb transplantation. Following allogenic hind‐limb transplantation, Lewis rats were either left untreated[1][Shores JT, 2015] or treated with anti‐lymphocyte serum + tacrolimus (baseline)[2][Kanitakis J, 2003];...
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