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Insulin degrading enzyme (IDE) is a metalloprotease that has been involved in amyloid β peptide (Aβ) degradation in the brain. We analyzed the ability of human brain soluble fraction to degrade Aβ analogs 1–40, 1–42 and the Dutch variant 1–40Q at physiological concentrations (1 nM). The rate of synthetic 125I-Aβ degradation was similar among the Aβ analogs, as demonstrated by trichloroacetic acid...
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