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Both clinical observations and experimental findings in humans demonstrate that humoral and cell-mediated immune responses markedly differ between sexes. In line with this, we have recently shown that women mount stronger pro-inflammatory and weaker anti-inflammatory cytokine responses after in vivo challenge with bacterial endotoxin compared to men, but the underlying mechanisms remain elusive. Given...
Patients with inflammatory conditions commonly suffer from non-specific bodily symptoms such as fatigue, widespread pain, and malaise. However, it remains unclear if these symptoms are driven by cytokines and/or psychological factors. Experimental administration of endotoxin (LPS) is an established model to induce a wide spectrum of behavioral and physical sickness symptoms. The aim of the present...
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