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S 3483, a synthetic derivative of chlorogenic acid (CHL), was found to be a reversible, linear competitive inhibitor of the glucose-6-phosphatase (Glc-6-Pase) system in rat renal microsomes and rat and human liver microsomes. TheKifor S 3483 in rat liver microsomes (129 nM) is three orders of magnitude smaller than theKifor CHL. S 3483 up to 100 μM had no effect on the Glc-6-Pase enzyme activity or...
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