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Adenosine, a well-known neuromodulator, can act as an endogenous anticonvulsant via the activation of adenosine A 1 receptors. This adenine nucleoside can be produced in the synaptic cleft by the ectonucleotidase cascade, which includes the nucleoside triphosphate diphosphohydrolase (NTPDase) family and ecto-5′-nucleotidase. It has been previously reported that ectonucleotidase activities...
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