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The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself. Herein we report a straightforward approach to encapsulate native proteins by using breakable organosilica matrices...
In einer zerbrechlichen Schale eingeschlossene Proteine können in Zellen transportiert und anschließend freigesetzt werden. L. De Cola, E. A. Prasetyanto et al. beschreiben in ihrer Zuschrift auf S. 3384 ff. eine solche Schale, die aus disulfidverbrückten Siliciumdioxideinheiten aufgebaut ist. Nach Überführung der eingeschlossenen Proteine in die Zelle werden die Disulfidgruppen durch Reduktion gespalten,...
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