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Stroke is commonly caused by thromboembolic events originating from a ruptured carotid plaque. Histological studies have shown that plaque rupture potential is related to plaque composition rather than degree of stenosis. The use of Acoustic Radiation Force Impulse (ARFI) ultrasound imaging has enabled assessment of carotid plaque composition and structure. In particular, a previous study has shown...
Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque, with rupture potential related to plaque composition. We have previously shown that soft (intraplaque hemorrhage/necrotic core) and stiff (collagen/calcium) plaque components are differentiated with high sensitivity and specificity by peak displacement (PD) in Acoustic Radiation Force Impulse (ARFI) imaging...
Stroke is commonly caused by thromboembolic events originating from vulnerable atherosclerotic plaque in the carotid vasculature. The purpose of this study was to evaluate the ability of acoustic radiation force impulse (ARFI) imaging, a noninvasive elastography imaging technique, to assess the composition of carotid artery plaques using histologic examination as the gold standard. Twenty-five patients...
Atherosclerotic plaque characterization with acoustic radiation force impulse (ARFI) imaging has recently been developed using phantoms and atherosclerotic pigs, but has yet to be validated in vivo in humans. We present initial results from an ongoing clinical trial investigating in vivo ARFI imaging of human carotid plaque with spatially-matched histopathology. Patients undergoing clinically-indicated...
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