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Transforming growth factor (TGF) β1 is a potent inducer of apoptosis in the liver. During TGF-β1-induced apoptosis, 3 mitogen-activated protein (MAP) kinases (extracellular signal-regulated kinase [ERK], c-Jun N-terminal kinase [JNK], and p38 kinase) showed simultaneously sustained activation in FaO rat hepatoma cells. TGF-β1-induced apoptosis was markedly enhanced when ERK activation was selectively...
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