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Growing understanding of the molecular characteristics of breast cancer is raising the possibility of ultimately delivering therapies that are tailored to the tumour biology of the individual patient. Agents that are currently being evaluated in metastatic breast cancer, irrespective of specific markers such as human epidermal growth factor receptor-2 (HER2) or oestrogen receptor, include the novel...
The third-generation aromatase inhibitors (AIs) are gradually displacing tamoxifen as the preferred adjuvant endocrine treatment for hormone-receptor-positive early breast cancer in postmenopausal women, having demonstrated superior efficacy in clinical trials. However, for the AIs to gain widespread acceptance in the adjuvant setting, good long-term tolerability must also be demonstrated, particularly...
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