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There is a high prevalence of myofascial pain in people with hypermobile Ehlers‐Danlos Syndrome (hEDS). The fascial origin of pain may correspond to changes in the extracellular matrix. The objective of this study was to investigate structural changes in fascia in hEDS. A series of 65 patients were examined prospectively—26 with hEDS, and 39 subjects with chronic neck, knee, or back pain without hEDS...