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Fibrodysplasia ossificans progressiva (FOP) leads to disabling heterotopic ossification (HO) from episodic flare‐ups. However, the natural history of FOP flare‐ups is poorly understood. A 78‐question survey on FOP flare‐ups, translated into 15 languages, was sent to 685 classically‐affected patients in 45 countries (six continents). Five hundred patients or knowledgeable informants responded (73%;...
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