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Both advanced glycation end products (AGEs) and endoplasmic reticulum (ER) stress play important roles in the development of various diseases. This study aimed to clarify the consequence of AGE-induced ER stress and its underlying mechanisms in human umbilical venous endothelial cells (HUVECs).AGE-induced ER stress was assessed by the increased expression and activation of the ER stress marker proteins...
To investigate the protective effects of 17β-estradiol postconditioning against ischemia/reperfusion (I–R)-induced gastric mucosal injury in rats.The animal model of gastric ischemia/reperfusion was established by clamping of the celiac artery for 30min and reperfusion for 30min, 1h, 3h, 6h, 12h or 24h. 17β-estradiol at doses of 5, 50 or 100μg/kg (rat) was administered via peripheral veins 2min before...
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