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In this second part of our review article on the preferred screw sense and interconversion of peptide helices, we discuss the most significant computational and experimental data published on helices formed by the most extensively investigated categories of noncoded α‐amino acids. They are as follows: (i) N‐alkylated Gly residues (peptoids), (ii) Cα‐alkylated α‐amino acids, (iii) Cα,β‐sp2 configurated...
In this article, we review the relevant results obtained during almost 60 years of research on a specific aspect of stereochemistry, namely handedness preference and switches between right‐handed and left‐handed helical peptide structures generated by protein amino acids or appropriately designed, side‐chain modified analogs. In particular, we present and discuss here experimental and theoretical...
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