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Neural precursor cells (NPCs), which are capable of self-renewing, migrating to specific sites, and differentiating into the three main CNS lineages, neurons, astrocytes and oligodendrocytes, have been used experimentally to repair the damaged nervous system, either by grafting of cells grown in vitro or by activating endogenous NPCs. The grafting of NPCs, however, is limited by its lower viability...
Conditioned medium obtained from B104 neuroblastoma cells (B104CM) has been used widely for inducing oligodendrocyte progenitor cells (OPCs) from neural precursor cells (NPCs). Our previous studies have demonstrated that E16 rat spinal cord-derived NPCs could be induced to differentiate into OPCs using a combination of B104CM and basic fibroblast growth factor (bFGF). Here we report the development...
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