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Introduction: It has been reported that particular subtypes of DR4 may contribute to IDDM susceptibility. Twenty-four different alleles (DRB1 * 0401-0424) encoding the b chain of the serological defined DR4 specificity, can be identified at the genomic level. Some studies have shown that DRB1 * 0401, * 0402 and * 0405 are associated with IDDM susceptibility whereas...
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