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Thrombin‐binding aptamer‐conjugated gold nanoparticles (TBA‐Au NPs) for highly effective control of thrombin activity towards fibrinogen are demonstrated. While a 29‐base long oligonucleotide (TBA29) has known no enzymatic inhibitory functions for thrombin‐mediated coagulation, the ultrahigh anticoagulant potency of TBA29‐Au NPs can be demonstrated via the steric blocking effect, at two orders of...
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