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Inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R) acts as a ligand-gated channel that mediates neuronal signals by releasing Ca 2+ from the endoplasmic reticulum. The three-dimensional (3D) structure of tetrameric IP 3 R has been demonstrated by using electron microscopy (EM) with static specimens; however, the dynamic aspects of the IP 3 R structure have...
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