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Cetuximab was approved using a weekly schedule, alone or in combination with chemotherapy (CT). However, many CT regimens in metastatic colorectal cancer (CRC) are delivered every 2 weeks (q2wks). Preliminary data suggested that a simplified schedule using cetuximab q2wks, 500 mg/m² would be equivalent to the standard weekly administration. Medical data of all patients with advanced CRC who received...
Résumé: La constatation que le récepteur EGF (Epidermal Growth Factor Receptor) et PDGFR (Platelet- Derived Growth Factor Receptor) sont impliqués dans les métastases osseuses ouvre de nouvelles perspectives thérapeutiques. Il s’agit d’une nouvelle approche qui devrait permettre le développement de nouveaux agents thérapeutiques que sont les inhibiteurs EGFR/HER2 et les antagonistes de PDGFR.
Résumé: Les bisphosphonates (BP) inhibent la résorption osseuse associée aux métastases osseuses ostéoblastiques et interfèrent avec leur formation et leur croissance. Plusieurs études randomisées et non randomisées indiquent que les BP peuvent ëtre utilisés pour soulager la douleur osseuse due aux métastases du cancer de la prostate et diminuer l’incidence des complications osseuses tels la fracture...
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