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Using high pressure liquid chromatography, we find more brainstem 5‐HT and 5‐HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5‐HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.
[3H]CUMI‐101 is a 5‐HT1A partial agonist, which has been evaluated for use as a positron emission tracer in baboon and humans. We sought to evaluate the properties of [3H]CUMI‐101 ex vivo in awake rats and determine if [3H]CUMI‐101 can measure changes in synaptic levels of serotonin after different challenge paradigms. [3H]CUMI‐101 shows good uptake and good specific binding ratio (SBR) in frontal...
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