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PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis...
Acute organophosphate (OP) poisoning is lethal due to irreversible acetylcholinesterase (AChE) inhibition in neuromuscular junctions (NMJ). Recently, we discovered that AChE levels are down-regulated by microRNA-132 (miR-132) and that blocking this down-regulation can significantly elevate endogenous AChE levels [1]. Here, we report effective prophylactic protection from paraoxon poisoning of BalbC...
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