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Laser speckle contrast imaging (LSCI) has classically been used to image regional blood flow changes in animal models. In this paper, we demonstrate the use of LSCI for elucidating blood flow characteristics in individual microvessels with diameters as small as 24μm. We extracted profiles of speckle contrast values within individual vessels, both along their diameters and along their lengths and inferred...
Brain's functional response can be studied by observing the spatiotemporal dynamics of functional and structural changes in cerebral vasculature. However, very few studies explore detailed changes at the level of individual microvessels while revealing the simultaneous wide field view of microcirculation responses to functional stimulation. Here we use a high spatiotemporal resolution laser speckle...
Laser speckle imaging (LSI) and optical intrinsic signal (OIS) imaging are shown to produce high resolution information of cerebral blood flow (CBF) and de-oxygen hemoglobin (dHb) respectively. However, the cortex curvature and non-uniform illumination always result in the inhomogeneous impact and thus distort the CBF and dHb results. In this paper, we propose to extract both CBF and dHb images from...
A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses...
The cortical vascular blood flow pattern is associated with the functional response in cerebral cortex. The pattern of the vascular blood flow can be used to study the spatiotemporal activities of the somatosensory center and the diagnosis of the focal stroke or ischemia. In this present study, temporal laser speckle analysis is used to obtain the cortical blood flow information. By centerline modeling...
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