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Glioblastoma (GBM) is the most common primary malignant brain cancer in adults with a dismal prognosis. Temozolomide (TMZ) is the first‐in‐line chemotherapeutic; however, resistance is frequent and multifactorial. While many molecular and genetic factors have been linked to TMZ resistance, the role of the solid tumor morphology and the tumor microenvironment, particularly the blood‐brain barrier (BBB),...
Microfluidic Models
In article number 2302280, Andrea Pavesi and co‐workers develop an in vitro 3D glioblastoma model, that incorporates a perfusable blood‐brain barrier. The model recapitulates key features of clinical disease, such as a diffusive infiltrating tumor front and tumor‐associated dysregulation of vascular permeability. The authors further demonstrate the compatibility with next‐generation...
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