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ELDKWA on HIV-1 gp41 is a conserved epitope recognized by one broadly neutralizing monoclonal antibody 2F5, which is a promising candidate target for vaccine design. Here we report two ELDKWA-specific monoclonal antibodies (mAbs), 18F11 and 7E10, that were screened from the splenocytes of mice immunized by recombinant GST-(ELDKWA) 4 protein. In further evaluation, these mAbs exhibited appreciable...
The multiple sequence and antigenic variability of HIV-1 has led to unprecedented difficulties in the development of effective vaccines. More and more experimental evidence suggests that HIV-1 mutants have resulted in immune evasion and pose a challenge for conventional efforts to prepare effective vaccines. We have suggested that an epitope-vaccine could offer a new strategy against HIV-1. Several...
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