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Apoptosis of preadipocytes and adipocytes contributes to the balance of adipose tissue mass by reducing adipocyte number. To address this phenomenon, we treated cultured rat S-V cells with all-trans-retinoic acid (RA) (10 μM) or C2-ceramide (50 μM) during adipogenesis. Gel electrophoresis of DNA from treated cells cultured in serum-free medium showed that 10 μM RA or 50 μM ceramide induced a distinct...
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