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Phenobarbital, a potent inducer of CYP2B isozyme of cytochrome P450, induces mainly CYP2A but not CYP2B in the Chinese hamster liver. A major isozyme inducible by phenobarbital was purified by column chromatography from Chinese hamster livers. This isozyme, named P450 CH2A-2 and designated CYP2A14, had in the reconstituted system high activities of 7-ethoxycoumarinO-deethylase...
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