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Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the maternal immune system. The unique characteristics of both cell-surface and soluble...
The expression of inhibitory immunoglobulin-like transcripts (ILTs) on dendritic cells (DCs) is a biomarker of tolerogenic DCs. In this article we discuss current knowledge on the function of ILTs and explore the molecular mechanisms involved in modulation of DCs via the inhibitory receptor and its natural ligand, rendering these cells tolerogenic. We propose a method to enhance targeting of inhibitory...
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