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Aortic stenosis (AS) severity contributes to the left ventricle (LV) deterioration due to the aortic valve narrowing and the alteration of systemic hemodynamic load. This load increment may also increase the LV stroke work (SW) which represent the required energy to deliver the blood at ejection. In this study, SW was derived from in-vivo cardiovascular magnetic resonance (CMR) velocity measurements...
The determinants of maximal exercise capacity (MEC) in aortic stenosis (AS) are, in large part, unknown. We hypothesized that the left ventricular (LV) global hemodynamic load – as assessed by the valvulo-arterial impedance (Zva) – is one of the main determinants of MEC and we sought to evaluate the factors associated with reduced MEC in AS.Asymptomatic patients with moderate or severe AS (n=62, aortic...
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