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Pioglitazone is a thiazolidinedione (TZD) class of antidiabetic drug acting mainly through activation of PPARγ which is a member of family of ligand activated nuclear hormone receptors. Clofibrate is an antilipemic drug acting through activation of PPARα. Despite the impressive antidiabetic activity of TZD, several side effects are implicated to use of this drug on some patient. Dual acting PPARα/γ...
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