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Objective
Myeloperoxidase (MPO) locally contributes to organ damage in various chronic inflammatory conditions by generating reactive intermediates. The contribution of MPO in the development of experimental lupus is unknown. The aim of this study was to define the role of MPO in murine lupus nephritis (LN).
Methods
LN was induced in C57BL/6 wild‐type (WT) and MPO knockout (MPO–/–) mice by intraperitoneal...
ObjectiveAutoantibodies constitute the hallmark of antineutrophil cytoplasmic antibody–associated vasculitis (AAV); however, CD4+ T cells play an essential role in the development of autoimmunity. Infection is associated with vasculitis, with Toll‐like receptors (TLRs) a potential link between infection and autoimmunity. This study was undertaken to investigate the role of TLR ligation on cellular...
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